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TumorExosomesReprogrammedbyLowpHAreEfficientTargetingVehiclesforSmartDrugDeliveryandPersonalizedTherapyagainsttheirHomologousTumor

AdvancedScience

Asmembrane-boundextracellularvesicles,exosomeshavetargetingabilityforspecificcelltypes,andthecellularenvironmentstronglyimpactstheircontentanduptakeefficiency.Aimingtotheanticancerdrugdelivery,theauthorshereininitiallyscreenedtheimpactsofsixdifferentcellularstressconditionsontheuptakeefficiencyofexosomesreleasedbythehumangastriccancercellline.TheyfoundthatlowpHtreatmentinducedthemostprominentenhancementofexosomesuptakeintoparentcells.Uponfurtherdiscoveryofalteredlipid

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